THE SCIENCE OF CIRCADIAN RHYTHMS

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Circadia proudly offers a skincare philosophy backed by decades of scientific research, formulation expertise, and a deep understanding of the body’s natural circadian rhythms. Circadia's professional-grade skincare solutions are designed to elevate treatment outcomes and support skin health. 

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A Scientific Legacy Led by Innovation

Circadia was founded on the pioneering work of Dr. Peter T. Pugliese, a visionary in skin science whose research into the role of circadian rhythms in skin function transformed the way we understand skincare. Today, Circadia remains a family-owned business, with Dr. Pugliese’s legacy carried forward through advanced formulations that align with the body's natural biological clock to support optimal skin health and function.

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The Power of Circadian Rhythms in Skincare

The name Circadia comes from the Latin phrase “circa diem,” meaning “around the day.” Circadian rhythms are 24-hour cycles that influence everything from hormone release to cellular regeneration, including the skin’s ability to protect, repair and renew itself.

When these rhythms are disrupted by stress, poor sleep, blue light exposure, or environmental factors, skin can experience premature ageing, inflammation and decreased efficacy of topical products. Circadia’s formulations are developed to work with these natural cycles, offering protection during the day and supporting cellular repair at night through chronobiological science.

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Advanced Technologies and High-Performance Ingredients

Circadia’s commitment to innovation is evident in its use of sophisticated ingredients and delivery systems that enhance skin results while maintaining a clinical clean profile; free from parabens, artificial fragrance and SLS.

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Plant Stem Cell Technology

Circadia uses plant-based stem cell extracts to target inflammation, oxidative stress, and premature aging. Key actives include:

• Malus Domestica (Apple Stem Cell) – Supports skin longevity and reduces wrinkle depth

• Edelweiss – Protects against environmental stress

• Gardenia – Hydrates and strengthens the skin barrier

• Grape Stem Cell – Offers powerful antioxidant protection

• Lilac Stem Cell – Ideal for balancing oily, acne-prone skin

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Second-Generation Vitamins

Stabilised vitamin derivatives in Circadia formulations offer greater efficacy with minimal irritation:

• Vitamin A (Retinol & Retinyl Acetate) – Smooths skin and improves texture

• Vitamin B (Niacinamide & Panthenol) – Brightens, calms, and strengthens the skin

• Vitamin C Derivatives – Brighten, protect, and support collagen synthesis

• Vitamin E (Tocopherol & Tocotrienol) – Neutralises free radicals and supports recovery

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Peptide Innovation

Circadia utilises peptides to visibly reduce fine lines and improve elasticity:

• Matrixyl™ / Matrixyl™ 3000 – Boost collagen and reduce wrinkle volume

• Snap-8® – Minimises expression lines

• Progeline™ – Firms and remodels skin

• Inyline® – Targets dynamic wrinkles

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Signature Treatments That Deliver Real Results

Circadia’s clinical treatments blend science and nature to deliver transformative results with minimal downtime. These include:

SWiCH™ Dermal Rejuvenation System – An innovative alternative to traditional peels, designed to trigger cellular energy and repair mechanisms without damaging the skin’s barrier.

Oxygen Rx Facial – A unique treatment that generates oxygen on the skin to calm, brighten and purify, ideal for rosacea and acne treatments.

Enzyme Facials – Natural enzymes like papaya and pineapple gently exfoliate while nourishing the skin for a radiant glow.

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Clinical, Clean, Made in the USA

As a vertically integrated manufacturer, every Circadia product is developed, tested, and produced in our own state-of-the-art facility in Leesport, Pennsylvania. This allows for quality control, transparency and innovation across every stage of production.